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Similarly, Ortega et al

RRBS, reduced representation bisulfite sequencing

After incubation at 37 C for 34 h, DNA templates were digested with RQ1 DNase (Promega, M6101) at 37 C for 30 min

Ethics declarations Competing interests KGW and VJNB are co-founders and shareholders of Aprea Therapeutics AB, a company that develops novel p53-based cancer therapy

Additionally, the controllable and tunable fluorescence properties of CDs, which can be modulated by preparation methods and precursor materials, make them highly promising for drug analysis, as changes in their fluorescence intensity or state can be induced by external stimuli 19,28,29,30,31