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In mammals, GS is expressed primarily in the liver, brain, and muscle

Similarly, two members of the anthracycline antibiotic family, doxorubicin and daunorubicin hydrochloride decreased H 2 S production in HepG2 cells (Figure 3B, upper panels) although they induced cell toxicity at higher concentrations (Figure 3B, lower panels)

Their pups were divided into six groups of eight (three male and three female): a control group receiving normal saline, a social isolation stress group (SIS + NS) also receiving saline, and a social isolation stress group treated with intraperitoneal NAC (SIS + NAC)

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These pathways include the cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis 1,4 , the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q 10 (CoQ 10 ) axis on the plasma membrane 5,6 , the guanosine triphosphate cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) axis 7,8 , and the mitochondrial dihydroorotate dehydrogenase (DHODH)/CoQ system 9