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The excessive accumulation of cholesterol in macrophages activates the inflammasome NOD-like receptor thermal protein domain associated protein 3 (NLRP3), a protein that cleaves IL-1 precursor into its active form and enhances the expression of cytokines [116]
Globally, excess body weight is responsible for about 4 percent of all cancer cases (75)
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Ref Type: Generic Veronese FM, Nyc JF, Degani Y, Brown DM, Smith EL: Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of Neurospora
