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The design integrates several key components, as outlined below: the chosen CBBBP is Tat, identified through prior animal experimentation from two candidate peptides for its superior efficacy in facilitating the transport of therapeutic agents crossing BBB

In his study, Yu et al

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Studies using bortezomib as monotherapy for desensitization have shown less promising results with poor reduction of anti-HLA antibodies and significant toxicity with longer courses of the drug (99, 100) that have caused enthusiasm for its use in new desensitization regimens to wane