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The animal care and experimental procedures were carried out in accordance with the European Communities Council Directive (86/609/EEC) and were also approved by the Northern Swedish Committee for Ethics in Animal Experiments (Permit Number: A127-10)

NF-B regulates the expression of almost 500 different genes, including enzymes [e.g., cyclooxygenase (COX)-2, 5-lipoxygenase (LOX), and inducible NO synthase (iNOS)], cytokines [such as interleukin (IL)-1, IL-6, IL-8, chemokines, and tumor necrosis factor (TNF)], adhesion molecules, cell cycle regulatory molecules, and angiogenic factors (Duh et al., 1989

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[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Wambebe C.O., Bamgboye E.A., Bidemi O.B., Hadiza K., Jafaru A.M., Ekpeyong M., Benedict S.A., Njoku S.O., Nasipuri N.R., Olubayo O.K., et al