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As with all fat reduction treatments it is not a substitute for a healthy lifestyle, including proper diet and exercise, and results will not be maintained unless these factors are also considered

Another nationwide study of 3.8 million individuals found that high non-HDL-C consistently predicted myocardial infarction and stroke, with stronger associations than LDL-C and sustained across age, sex, diabetes, hypertension, and statin use

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Of note, PDT is less effective in organ transplant recipients on long-term immunosuppression

Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins