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The deficiency of Nrf2 in Nrf2 knockout (KO) mice attenuated the chondroprotective effect of metformin on OA development, further affirming the core position of Nrf2 signaling during metformin fights illness as an antioxidant

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The current study intends to explore the individual and combined toxic effects of Cr and Cd in the brain of Swiss albino mice in addition to examining the possible neuroprotective functions of coenzyme Q10 (CoQ10), biochanin-A (BCA), and phloretin (PHL), the naturally occurring flavonoids with antioxidant qualities