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The adverse events (AEs) experienced by test subjects who were given Fragment 176-191 were minor and included headaches, injection site swelling, and nausea

In a 2024 case study, researchers reported one instance of mixed-state bipolar disorder that may have been triggered by vitamin B12 overdose

Cats with IBD, pancreatitis and intestinal lymphoma have low levels of vitamin B12

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The blue ranges are then available Hammett function values for the given protic solvent, similarly as there is range of available pH values for water solutions