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For patients with a diagnosed deficiency, B12 injections may be given daily or weekly during the initial correction phase, then monthly for maintenance

also, similar to MSCs, the differentiation potential of disc progenitor cells is affected by hypoxia: hypoxia promotes chondrogenic differentiation of NP progenitor cells and inhibits osteogenic differentiation of human endplate (CEP) progenitor cells (Li et al., 2013

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This does not diminish GHK-Cu

Investigators administered BPC-157 by three routes intraperitoneal injection, oral administration in drinking water, and topical application as a thin cream layer with assessment over a 90-day post-injury period
