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Golgi-associated S protein may be identified for retrograde trafficking by its association with Golgi-resident CoV M proteins 3,12 , consistent with its dependence on cis-Golgi-located M protein for incorporation into virions 6,12

For the purpose of these studies we employed a C57Bl/6xCBA F1 hybrid cross (F1) mouse model since the age-dependent oocyte deterioration previously documented in this strain, mirrors that which occurs in humans

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The two most important SH2 molecules at this point are the adaptor molecule Grb2 and the enzyme PI3K[251, 252]