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Furthermore, a chronic inflammatory state in the nervous system intensifies with age, leading to increased microglial activation and elevated levels of proinflammatory cytokines, such as tumor necrosis factoralpha (TNF) and interleukin1 beta (IL1), detectable even preclinically [63, 64]

Hens for their technical support of this study and for taking care of the animal facility management

Meister, Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione

doi: 10.1194/jlr.C600019-JLR200 38 HosnedlovaB.KepinskaM.SkalickovaS.FernandezC.Ruttkay-NedeckyB.PengQ.et al

The regulation of the different roles of GSH and the precise mechanisms by which it acts as a signal transducer under metal-induced oxidative stress is currently under intense investigation and will provide essential information to understand the cellular responses to metal toxicity