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Active Akt phosphorylates multiple targets including Bad (preventing it from inhibiting anti-apoptotic Bcl-2), MDM2 (stabilizing p53), FOXO transcription factors (preventing pro-apoptotic gene expression), mTOR (promoting protein synthesis)

Think of them as highly specific signals that can turn on or turn off cellular functions with incredible accuracy

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Finally, a score of 5 corresponds to ulcers extending beyond 2 cm, accompanied by marked intestinal thickening and severe adhesion to surrounding organs

In rat models of colitis which mimic human IBD BPC-157 significantly sped up mucosal healing, reduced inflammatory markers, and improved the animals weight and wellbeing