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Regulatory Toxicology and Pharmacology., 73 , 463476

By blocking the channels, cisplatin interferes with potassium ion flow, which disrupts normal neuronal signaling

A randomized, double-blind, controlled phase II trial in advanced renal cell carcinoma (RCC) demonstrated synergistic anticancer effects with the combination of the glutaminase inhibitor telaglenastat (CB-839) and the mTOR inhibitor everolimus (TelaE), which was well tolerated by patients previously treated with TKIs

This makes it a significant molecule in combating the signs of ageing and maintaining overall cellular health

[DOI] [PubMed] [Google Scholar] 67.Dengler E.C., Liu J., Kerwin A., Torres S., Olcott C.M., Bowman B.N., Armijo L., Gentry K., Wilkerson J., Wallace J