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Consistent with this mechanism, Tat upregulates miR-505, which represses SIRT3, leading to ROS accumulation, mitochondrial stress, and a senescence-like microglial phenotype

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That condition can cause severe or even life-threatening problems when it goes untreated

AACR:210, 1994

1 Glutamine, Glutamate, and GABA: Metabolic Aspects
