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One of the possible reasons that anaemia is much less prominent in B12 deficiency than lets say 30 years ago, is that many countries have started mandatory fortification of food with folate

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Usually it is given every week by injection for four weeks in a row, then every other week for a month, then once a month going forward long-term

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Activation in the area postrema (AP) The area postrema is a circumventricular organ , a region of the brain that has no blood-brain barrier , so peptide hormones from the blood have direct access to it