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3.2 Post-translational modifications and protein stability of GPX4 The protein abundance and functional activity of GPX4 are not solely determined by transcriptional levels but are precisely regulated by a series of complex post-transcriptional and post-translational modification events, including but not limited to ubiquitination, interaction with specific proteins, and potential phosphorylation and glycosylation (Huo et al., 2024)

SIBO was present in 31% of patients with MCAS, and the authors concluded that mast cell mediators in the gut may contribute to altered digestive motility, which could lead to SIBO

Furthermore, silymarin has been shown to reduce the fatty liver index and improve the hepatic steatosis grade, which is a critical measure of the severity of NAFLD

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When all these toxins accumulate in our bodies, they can overload the liver and its ability to get rid of them, which, as you can guess, causes diseases