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[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Potthoff M.J., Wu H., Arnold M.A., Shelton J.M., Backs J., McAnally J., Richardson J.A., Bassel-Duby R., Olson E.N

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

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Thus, a dysfunction of the pentose phosphate pathway is likely to disrupt multiple cellular functions and cause a diverse cellular phenotype, such as the one seen in DADA2

Our previous studies have reported similar evidence in hepatocytes with low B12 demonstrating upregulation of FA and TG synthesis [14], and increased adiposity via hypomethylation and upregulation of the master regulators of lipogenesis (SREBF1) and cholesterologenesis (LDLR) in adipocytes [13]