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Mutations in genes crucial for LRO biogenesis are implicated in several inherited rare disorders developing co-existing symptoms of hypopigmentation, immunodeficiency, bleeding diathesis, and neuropathy (e.g., Hermansky-Pudlak Syndrome, Chediak-Higashi Syndrome, Griscelli Syndrome) 4,5
Instead, hsp-70 induction was dependent on pmk-1
Front Endocrinol (Lausanne) 6 42
Common approaches include asking patients to rate fatigue intensity (010 scale) and using validated questionnaires
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