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2.1.3 Immune pathways Immune signaling is another crucial component of gut-brain communication (Kasarello et al., 2023)

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Being an antidepressant belonging to the class of serotonin-2 antagonist/reuptake inhibitors, TRZ is a potent and selective postsynaptic 5-HT 2A antagonist and a moderately potent serotonin reuptake inhibitor, with high affinity for 5-HT 2A receptors and moderate affinity for 5-HT 1A and 5-HT 2C receptors [14,15,16]

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LPS administration induced significant phosphorylation of NF-B p65 (Ser536), p38 MAPK, and JNK1/2 in lung homogenates