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This dual inhibition contributes to the suppression of pro-inflammatory mediators, including NO and PGE2, underscoring the therapeutic potential of melittin and BV in managing RA and other inflammatory conditions ( Synthetic melittin has been shown to bind to PLA2 and inhibit the enzymatic activity of secretory PLA2 (sPLA2) in synovial fluid taken from RA patients

[Google Scholar] 60.Reidy DL, et al

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PLoS One 12(11):e0187504 Jain M, Ghanashyam C, Bhattacharjee A (2010) Comprehensive expression analysis suggests overlapping and specific roles of rice glutathione Stransferase genes during development and stress responses

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