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LNP delivered mRNA encoding the Cas9 endonuclease and sgRNA targeting KLKB1 to the liver, which disrupted the production of plasma prekallikrein and thus reduced the total plasma kallikrein protein level

2008 Dec 1;49(4):369-76

& Stern, G

Taken together, these results suggest that the virus-inducible gene OsVIRK1 plays a positive role in rice defense against RSV
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