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Description
These conditions include severe hypoxia, dehydration, increased sympathetic outflow, hypothermia, hyperthermia, high 2,3-BPG levels, or enhanced inflammatory status

10.1111/j.1749-6632.1993.tb39148.x

Okuda, S

In earlier trials, nearly half of patients experienced common adverse effects like injection site pain, rash, headaches, muscle soreness, nausea and fevers after the second injection
the nearby capillaries deliver hormone products to the blood supply
