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The structure of the ubiquitous enzyme glutathione reductase (EC 1.6.4.2), which helps protect cells from oxidative stress, is similar to trypanothione reductase (EC 1.6.4.8), lipoamide dehydrogenase (EC 1.8.1.4), higher eukaryotic thioredoxin reductase (EC 1.6.4.5) and mercuric reductase (1.16.1.1)

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Thus, p53 did not appear to suppress ferroptosis by reducing ABBC1 /MRP1 function

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