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Treatment with the 13g LIPE-specific inhibitor significantly decreased the pSer129:total S ratio (Fig

and Mello, C.C

In human, the CLC7 activity could also be attenuated by PI(3,5)P 2 , which adjusted lysosomal pH 43,45

6 Although this dysfunction is insufficient to produce a systemic metabolic disorder, it could produce a brain disorder, because the brain requires much larger amounts of energy than other organs
