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The ectodomain of matriptase-2 plays an important nonproteolytic role in suppressing hepcidin expression in mice

Monobody selection against D-MCP-1 was carried out by TRAP (transcriptiontranslation coupled with the association of puromycin linker) display

There are significant differences in the diffusion characteristics and mechanism of ROS produced by Type I and Type II PDT, which directly affect the design strategy and therapeutic effect of the prodrug system: Type I PDT generates OH through electron transfer reactions, which has extremely strong oxidizing ability but a very short lifetime, and its diffusion distance in the biological environment is short

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Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex