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Preservation requirements Water-based formulations support microbial growth

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PEP must be started within 72 hours of the exposure, the earlier the better

However, dry powder formulations have attracted greater attention due to the dry powder particles greater drug stability and prolonged residence time in the nasal cavity compared to liquids, and also due to the potential to achieve the desired therapeutic drug levels in the brain by controlling the release rate of encapsulated drug [32]