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Description
In people with weakened immune systems, more serious issues such as pneumonia, hepatitis or encephalitis can occur
This muscle autocrine/paracrine/endocrine effect has various effects

A total of 539 patients were enrolled with 359 patients randomized to pemetrexed and 180 patients randomized to placebo

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The largest Phase 2b trial (502 participants, 24 weeks) did not show statistically significant weight loss versus placebo
