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As described above, the endothelium produces and activates molecules and inflammatory factors, which exit the bloodstream and reach the target tissue through the endothelium

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Immunometabolism and immune response regulate macrophage function in atherosclerosis

Methotrexate, an antifolate drug used in cancer therapy, is a known inhibitor of DHFR, the enzyme that catalyzes the conversion of DHF into THF, which is required for the de novo synthesis of nucleotides for both DNA and RNA

doi: 10.1016/j.cgh.2012.03.011 [DOI] [PubMed] [Google Scholar] 55.Du SX, Lu LL, Geng N, Victor DW, Chen LZ, Wang C, et al