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To examine the impact of a stronger social stress load, an additional cohort of P60-70 WT and KI mice was tested using a modified paradigm in which the duration of each defeat episode was extended to 5 min

Detoxification Glutathione binds to heavy metals, pollutants, and other harmful substances to render them water-soluble for easier excretion
SOCS1 is subsequently released and then binds to JAK2 to inhibit its kinase activity (147)
Physical and Emotional Withdrawal: A critical aspect involves recognizing withdrawal symptoms, both physical and emotional, when the individual is not consuming alcohol

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