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Description
Osthus et al
doi: 10.1038/s41389-021-00364-5
In PD, folate deficiency and hyperhomocysteinemia worsen motor deficits and nigral dopaminergic loss, with mechanistic links to glutathione depletion, mitochondrial dysfunction, oxidative stress and NLRP3-mediated inflammation [82, 171]
Indeed, mitochondrial dysfunction which is typically characterized by an ATP production deficiency and/or over production of ROS can lead to cell death and development of disease
In particular, the study by Samadi et al
