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The CMAs related to formulations materials, such as lipid ratio and emulsifier amount should be evaluated and the CPPs associated with the production techniques should be tested

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A randomized controlled trial (Phase 1 and 2) examined the efficacy of intracerebroventricular A-DA in PD patients with L-DOPA-related complications

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The glutamatergic system is the leading excitatory network in the brain, and the analyzed interventions focused primarily on modulating its major classes of receptors, including ionotropic N -methyl-D-aspartate receptors (NMDA), -amino-3-hydroxy-5-methyl-4-isoxazolopropionic acid (AMPA), and metabotropic glutamate (mGlu) receptors [49]