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Addressing Inflammation in Chronic Diseases: A Functional Medicine Perspective

This dosing asymmetry is well-documented in the peer-reviewed literature and is not a matter of interpretation

[19] The enzymes that use B 12 as a built-in cofactor are methylmalonyl-CoA mutase (PDB 4REQ [43] ) and methionine synthase (PDB 1Q8J)

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Individuals with certain genetic predispositionssuch as variants in methionine synthase (MTHFR) and cobalamin metabolism pathwaysmay respond more distinctly to B vitamin protocols
