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While the normal pancreas is composed predominantly of ALDH1L2-expressing acinar cells, the gradual replacement of normal tissue with ALDH1L2-negative tumour cells results in an increase in formate overflow that is clearly detected in the PDAC tumour interstitial fluid

thinner skin and reduced hepatic clearance in older patients may warrant smaller treatment areas and shorter exposure times

Elevated levels of 8-OHdG have been observed in various cancer tissues of ovarian, breast, prostate, nonsmall cell lung, esophageal, and colorectal cancers, whereas the surrounding healthy tissue contains low or negligible levels of this adduct

Then, the cells were treated with oleic acid (OA

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