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10.1016/j.arr.2020.101240 127 MattisonJ

ADH and ALDH activities vary from person to person, and the Asian population have a higher genetic deficiency in ALDH2 than those in the West [27]

This strongly suggests that earlyonset cases are more likely mediated by topdown mechanisms, driven by a stronger genetic/neurobiological vulnerability to central dysregulation

Structures and PK profiles shown in Figure 7 highlight the importance of understanding the limitations of commonly used dose optimization strategies and making timely tractability decisions for a given chemical series

Those are two completely different contexts, patients, and purposes one has nothing to do with the other, and the chemo dose is not something to replicate for cosmetic reasons