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By one month (II), these cells showed increased presence within the central regions of the graft, suggesting active participation in tissue remodeling

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for instance, H3K14 lactylation has been demonstrated to promote ferroptosis in endothelial cells exposed to lipopolysaccharide (LPS) by transcriptionally upregulating the TFRC (73)

Furthermore, the review explores novel drug delivery strategies, such as microsphere encapsulation, injectable hydrogels, Fc-fusion, and oral small-molecule formulations, aimed at achieving sustained and controlled release to reduce dosing frequency and improve patient compliance