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however, this does not involve -arrestin2 or NEDD4 (which are critical for agonist-induced ubiquitination), but requires a transmembrane RING-finger E3 ligase, MARCH2 (Membrane-associated RING-CH2) [102]

What are the complications of vitamin B12 deficiency

In clinical practices, combining conventional anti-tumor medications with adjuvant treatments has shown complementary and supplementary role that enhanced the safety and effectiveness while minimizing adverse effects of the applied therapeutic strategies, as evidenced by numerous clinical trials [277,278,279], namely on breast cancer (NCT03980509), prostate cancer (NCT03769766), cervical cancer (NCT04294836) and advanced pancreatic cancer (NCT00094445)

doi: 10.1016/s0733-8635(03)00082-2

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 digital issues and online access to articles $119.00 per year only $9.92 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Bloomfield, G