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Moderate improvement in binding affinity at the hMC4R was observed, likely due to proximity effects and increasing the moles of pharmacophore present, but not indicative of cooperative or multivalent binding

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Although we investigated only one agonist, other serotonin receptor subtypes (including HTR1, HTR2, HTR3, HTR4, HTR5, HTR6, and HTR7) may be present on the DP cell membrane 18