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The flies solely administered with L-DOPA performed better during initial exposure after which their progress declined, consistent with the reported pattern of wearing-off in L-DOPA administered PD patients 39,55

The generalizability of findings is also often limited by insufficient consideration of individual differences, such as genetic background, baseline nutritional status, gut microbiota composition, and specific OA phenotypes (e.g., metabolic vs

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20132435) where direct sgRNA capture was enabled

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