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Elevated glucose uptake and flux through glycolysis is a salient metabolic feature of many cancers 3

doi: 10.1093/toxsci/kfg181

Ghrelin in psychiatric disordersa review

(See CONTRAINDICATIONS, WARNINGS and DOSAGE AND ADMINISTRATION.) (See CONTRAINDICATIONS, WARNINGS and DOSAGE AND ADMINISTRATION.) No evidence of carcinogenecity was found in two 2-year bioassays in rats at doses up to 100 mg/kg, which is 24 and 4 times the maximum recommended human daily dose (MRHD) on a mg/kg and mg/m2 basis, respectively, or in a 2-year bioassay in mice at doses up to 80 mg/kg, which is 20 and 1.5 times the MRHD on a mg/kg and mg/m2 basis, respectively

Nonetheless, further investigations are warranted to fully elucidate the underlying mechanisms and optimize the treatment protocol for maximal clinical benefit