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If this internal ROS burst is blocked (as by high antioxidants or perhaps in certain metabolic states), Siglec-8-induced death might be less effective
Thus, we adopted a mutational approach to evaluate and confirm the role of the Lys8 residue in the enzymatic reaction
Goddard TD, et al

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However, recent studies have shown that neutrophil apoptosis and NETosis are not mutually exclusive processes