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Lewerenz, J., Hewett, S.J., Huang, Y., et al
Interfering with this interaction, therefore, allows p53 to cause senescent cells to enter apoptosis

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Once widespread rod cell death has occurred, cone photoreceptors gradually degenerate, causing visual loss and complete blindness

It activates the Nrf2 pathway and upregulates detoxification enzymes, such as glutathione S-transferase
