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In the absence of targeting moieties on the cell surface, the NDDS can be absorbed intact by enterocytes and M cells via an endocytotic pathway triggered by non-specific interactions such as hydrogen bonding or van der Waals interactions

1 2 J Int Med Res

Malaviarachchi, D., Veugelers, P

It can be seen that GPX7 plays an important role in oxidative stress and reducing the inflammatory responses in tissues and organs

All these studies suggested that in many AML patients, DTP cells development is induced by drugs through triggering epigenetic evolution and/or metabolic reprograming which mediate adaption to drug-stress in a subset of AML cells without a clear LSC feature