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These outcomes vary according to concentration, exposure duration, and experimental model, making GHKCu a versatile tool for studying copperdependent signalling and peptidemetal interactions in both in vitro and in vivo contexts

In LNCaP cells, oxymetazoline demonstrated more potent ERK 1/2 activation than treatment with noradrenaline, behavior that is commonly observed with -arrestins biased agonists

In the chronic toxicity experiment, L-NAME caused severe tissue damage (myocardial and hepatic cell necrosis, necrosis of the lymphoid cells in the spleen) while L-arginine provoked predominantly congestion, edema and hemorrhages in all organs

Biochim Biophys Acta Gen Subj 1721(13):8997

injectable GHK-Cu does not