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The diagnosis of PFPT had been made based on clinical findings of circumscribed pigmentation localized on fungiform papillae of the tongue and also in association with dermoscopic findings

Enterocytes isolated from insulin-resistant fructose-fed hamsters have considerably higher intracellular levels of non-esterified cholesterol, esterified cholesterol, and triglycerides, which may indicate enhanced lipogenesis ( In animal models of diabetes, increased expression of MGAT, DGAT, and the mature form of sterol regulatory element binding transcription factor 1c (SREBP-1c), a transcription factor promoting lipogenesis, has also been observed in intestinal cells

NS3, a 67 kDa polypeptide, possesses multifunctional activities

CDR3 amino acid sequence variability within the agonistic nanobody panel suggests that different nanobodies can stimulate MC4R signaling through different residue interactions and potentially different binding interfaces