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-adrenoceptor antagonist Nebivolol: Nebivolol is a -adrenoceptor antagonist with nitric oxide enhancement, vasodilation, and antioxidant effects
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APOE4 carriers display decreased levels of antioxidative stress response proteins such as superoxide dismutase 2 (SOD2) and forkhead-box protein O3a (Foxo3a) compared to non- APOE4 carriers

The dropout rate was low (only 6 participants didnt finish the study), indicating the study was carefully conducted and had few severe side effects
