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Emerging insights into the functions of pathogenesis-related protein 1

Loss of CCP1 or CCP5 results in pathological hyperglutamylation that precedes and drives progressive structural disorganization of the outer segment, characterized by destabilization of the distal axoneme, loss of the bulge region required for disc formation, and severe impairment of IFT

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Selective antagonists of the CysLT1 receptor, such as montelukast (Singulair), zafirlukast (Accolate), and pranlukast (Onon), are used in the treatment of asthma, asthma-related diseases, and a few nonasthma-related diseases (Fanning and Boyce, 2013, Riccioni et al., 2007, Sekioka et al., 2015)

The stomach is a hostile environment by design