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The type 2 immune response can be thought of as surveillance for tissue barrier sites, like the skin and airways, against parasites

Amino acids R847, R848, and K850 are potential candidates for electrostatic coordination of phosphoserine from the second CTD repeat

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In adolescents and adults, untreated disease may manifest as behavioral disorders, psychiatric symptoms such as depression, anxiety and psychosis, or cognitive decline (15)

Additionally, patients should be observed for signs and symptoms of megaloblastic anemia, such as fatigue, pallor, and anorexia