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Second, ROS and mitochondrial DNA (mtDNA), as damage-associated molecular patterns (DAMPs), along with pathogen-associated molecular patterns (PAMPs), may activate the NLRP3 inflammasome and induce the release of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, potentially transforming localized metabolic stress into a systemic inflammatory response

Autophagy induction further promotes radiosensitivity of glioma-initiating cells [120]

Data are mean SEM, n (all except leptin: V = 18, CS and WM = 19

Since the cytotoxicity to osteoblasts from lead or cadmium exposure was mediated in part by damage to cellular bioenergetics and induction of redox stress, agents able to mitigate redox stress may be useful for cellular preservation

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