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*BioMed Research International,* 2015:648108, July 2015

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Inherent Undermethylation Sets the Biochemical Foundation Many autistic children are born with a methylation imbalance , a trait inherited across generations

ROS are directly or indirectly associated with cytokine storm induction in SARS-CoV-2 infection, and ROS can activate NF-B and NLRP3 inflammasomes, thereby leading to the production of inflammatory cytokines and the development of acute respiratory distress syndrome and multiple organ dysfunction 62,63,64

In Prp-TDP-43 A315T mice, dysregulated expression of estrogen-related enzymes (CYP19A1 and CYP3A4) was observed relative to wild-type controls, which suggested that toxic phosphorylated TDP-43 oligomers may disrupt the balance between CYP19A1 and CYP3A4 expression, resulting in reduced estrogen biosynthesis and accelerated degradation