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10.1038/tp.2017.171 13 FlintJ.KendlerK

Subsequently, a phase I trial reported the treatment of relapsed chemotherapy-resistant ovarian cancer with the IL-12 plasmid/lipopolymer complex

In T2DM rats, GRg1 can reduce blood glucose, improve IR, and regulate lipid metabolism indicators (including TCHO, TG, LDL-C), while exhibiting hepatic protection and improving T2DM-related pathological indicators [207]

The reversible addition of -CH 3 groups is catalyzed by two enzymatic families, referred to as writers and erasers. Notably, DNA methyltransferases (DNMTs) are a large group of writer enzymes involved in de novo methylation and its maintenance, whereas Ten-eleven translocation (TET) dioxygenases primarily act as erasers catalyzing DNA demethylation (Fig